Nyos Quantum 220 Protein Skimmer fit check
Nyos Quantum 220 Protein Skimmer is an in-sump internal protein skimmer rated up to 500 gallons. Box ratings assume light stocking, so ReefCrafter scales them by bioload: about 335 gallons lightly stocked, 250 gallons medium, or 200 gallons for a heavily fed fish tank.
Nyos Quantum 220 Protein Skimmer: fits roughly 150-500 gallon systems. Specs, compatibility math, sizing risks, and alternatives before you buy.

Who it is for
Good fit for
- ✓ 150-500 gallon systems, per the catalog fit range.
- ✓ Heavily fed tanks up to about 200 gallons, or lightly stocked tanks up to about 335 gallons.
Not a fit for
- ✕ Tanks under about 150 gallons; it is sized above them.
- ✕ Systems over about 500 gallons without adding capacity elsewhere.
- ✕ Heavy-bioload tanks above about 200 gallons; the box rating assumes light stocking.
- ✕ Hang-on-back or AIO setups without a sump chamber deep enough for it.
Listed features
- in-sump
- needle-wheel pump
- whisper-quiet
- EQ upgrade compatible
Compatibility math
Bioload headroom
Example: On a 75g mixed reef, ReefCrafter wants about 150g of skimmer rating for medium bioload.
Nyos Quantum 220 Protein Skimmer is rated around 500g, so the useful question is whether that clears the fish load with margin.
Risk notes
- A skimmer can be fine for a light reef and thin for the same tank once feeding and fish load increase.
Professional fit context
- Compare rated maximum gallons, physical fit, cup clearance, noise, and bioload margin.
- Nyos Quantum 220 Protein Skimmer fits roughly 150-500 gallon systems; confirm that range against the final display volume, sump volume, and livestock plan.
Alternatives to compare
- Royal Exclusiv Bubble King Supermarin 200 Internal Protein Skimmer
Same 500 gallon rating; compare format and features instead.
- Reef Octopus Regal 300INT 12in Internal Protein Skimmer (VarioS)
Same 500 gallon rating; compare format and features instead.
- Royal Exclusiv Bubble King Double Cone 250 Protein Skimmer
400 gallon rating vs 500: less headroom, for smaller or lighter-stocked tanks.
Livestock this affects
- Tomini tang
Bioload score 2.3; size the skimmer for heavy feeding.
- Blue hippo tang
Bioload score 4; size the skimmer for heavy feeding.
- Snowflake moray eel
Bioload score 4; size the skimmer for heavy feeding.
- Achilles tang
Bioload score 3.8; size the skimmer for heavy feeding.
Full spec snapshot
- Category
- Skimmers
- Build tier
- Premium
- Estimated price
- $899
- Tank fit range
- fits roughly 150-500 gallon systems
- Format
- In Sump Internal
- Rated skimmer capacity
- 500 gal
Related reading
Questions
Is the Nyos Quantum 220 Protein Skimmer big enough for my tank?
It is rated up to 500 gallons. ReefCrafter wants 1.5x, 2x, or 2.5x the display volume in skimmer rating by bioload, so it fits about 335 gallons lightly stocked, 250 medium, or 200 heavily fed.
What tank size is the Nyos Quantum 220 Protein Skimmer for?
ReefCrafter's catalog fit range for it is 150-500 gallon systems. Confirm that against your final display volume, sump volume, and livestock plan rather than the box label alone.
What should I compare the Nyos Quantum 220 Protein Skimmer against?
Royal Exclusiv Bubble King Supermarin 200 Internal Protein Skimmer (Same 500 gallon rating; compare format and features instead); Reef Octopus Regal 300INT 12in Internal Protein Skimmer (VarioS) (Same 500 gallon rating; compare format and features instead); Royal Exclusiv Bubble King Double Cone 250 Protein Skimmer (400 gallon rating vs 500: less headroom, for smaller or lighter-stocked tanks).
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